Group detection, especially for large-scale scenes, has many potential applications for public safety and smart cities. Existing methods fail to cope with frequent occlusions in large-scale scenes with multiple people, and are difficult to effectively utilize spatio-temporal information. In this paper, we propose an end-to-end framework, GroupTransformer, for group detection in large-scale scenes. To deal with the frequent occlusions caused by multiple people, we design an occlusion encoder to detect and suppress severely occluded person crops. To explore the potential spatio-temporal relationship, we propose spatio-temporal transformers to simultaneously extract trajectory information and fuse inter-person features in a hierarchical manner. Experimental results on both large-scale and small-scale scenes demonstrate that our method achieves better performance compared with state-of-the-art methods. On large-scale scenes, our method significantly boosts the performance in terms of precision and F1 score by more than 10%. On small-scale scenes, our method still improves the performance of F1 score by more than 5%.